Although the scientific discipline of astronomy has made tremendous strides in understanding the nature of the universe and its contents, there remain some important unanswered questions. Answers to these may require the construction of new ground- and space-based instruments, and possibly new developments in theoretical and experimental physics.
* What is the origin of the stellar mass spectrum? That is, why do astronomers observe the same distribution of stellar masses—the initial mass function—apparently regardless of the initial conditions?[51] A deeper understanding of the formation of stars and planets is needed.
* Is there other life in the Universe? Especially, is there other intelligent life? If so, what is the explanation for the Fermi paradox? The existence of life elsewhere has important scientific and philosophical implications.[52][53]
* What is the nature of dark matter and dark energy? These dominate the evolution and fate of the cosmos, yet we are still uncertain about their true natures.[54]
* Why did the universe come to be? Why, for example, are the physical constants so finely tuned that they permit the existence of life? Could they be the result of cosmological natural selection? What caused the cosmic inflation that produced our homogeneous universe?[55]
* What will be the ultimate fate of the universe?[56]
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